The human skin is the body's largest organ and one of its most important defenses. It protects us from harmful pathogens while preventing vital fluids from escaping. But this strong protective barrier also creates a major challenge for scientists developing wearable health sensors. Many important chemical signals inside the body cannot easily pass through the skin.
Doctors can overcome this problem with implants such as continuous glucose monitors and cochlear implants. However, many existing implants can be relatively bulky, require batteries or involve invasive surgery. Smaller wireless and battery-free devices offer another option, but they often have limited surface area. This can weaken wireless power transfer and reduce the performance of their sensors.
Now, researchers from Imperial College London and the University of Southern California have developed a device designed to overcome these limitations. Called MiFi, or the Minimally Invasive Foldable bioelectronic implant, it is a tiny, origami-inspired implant that can change its shape depending on what is needed.
The device can be folded into a compact form for insertion and then unfold inside the body. This allows it to be small enough to reduce the need for major surgery while becoming large enough after implantation to support wireless power components and several sensors.
Details of the technology and its development have been published in the journal Advanced Materials.
Inspired by Origami
One of MiFi's most interesting features is its foldable structure. The device is made from flexible polyimide materials and has an accordion-like design. This structure allows the implant to collapse into a much smaller shape before insertion.
Once inside the body, the device can autonomously unfold and return to its larger, flat configuration.
This solves a major problem in implant design. A device needs to be small during implantation to make the procedure as simple and minimally invasive as possible. At the same time, it needs enough space after implantation to accommodate useful sensors and wireless components.
When fully unfolded, MiFi forms a square measuring about 2.1 by 2.1 centimeters. Despite its relatively large surface area, the device is only around 0.3 millimeters thick.
The researchers describe this as a "transient geometry," meaning the implant has one shape when it is being inserted and another when it is functioning inside the body.
No Bulky Battery Required
Another important feature is that MiFi does not depend on a large battery.
Instead, it uses near-field communication, or NFC, to receive power and transmit information. NFC is the same short-range wireless technology commonly used in contactless payment systems.
A nearby reader can provide the energy needed by the implant while also receiving data from its sensors. This approach could make the device smaller, lighter and potentially easier to use than implants that require built-in batteries.
The researchers tested the wireless system using a model made from pig skin. The results showed that MiFi could transmit data through more than 20 millimeters of tissue.
This is important because the wireless signal must travel through biological tissue before reaching an external reader. The results suggest that the system could communicate with a device placed close to the skin.
What Can MiFi Measure?
The researchers developed different versions of MiFi to demonstrate its potential for monitoring several conditions inside the body.
The device can measure heart rate and breathing rate, while other sensors can monitor temperature, tissue acidity and lithium levels.
The lithium sensor is particularly interesting. Lithium is used in some medicines, but maintaining the right amount in the body is important because the safe range can be relatively narrow. Excessive lithium levels can become toxic.
A device capable of monitoring lithium ions in the fluid surrounding cells could potentially provide doctors with information about medication levels without requiring repeated blood tests.
This demonstrates the broader potential of the technology. Instead of measuring only one health signal, future versions of such implants could potentially monitor several biological markers at the same time.
Tested in Living Tissue
To investigate whether the technology could operate in biological environments, the researchers carried out experiments using tissue samples and anesthetized rats.
The MiFi devices were implanted beneath the skin of the rats to demonstrate how the foldable system could be introduced into living tissue and operate after unfolding.
These experiments are an important early step, but the technology is still at the research stage. Animal and tissue experiments do not establish that a device is ready for use in humans. Additional studies will be needed to evaluate its long-term safety, reliability and performance before human clinical trials can be considered.
A New Approach to Personalized Healthcare
The potential advantage of MiFi is its combination of three features: minimally invasive insertion, a relatively large sensing area and wireless, battery-free operation.
Traditional implants often involve a trade-off. Making a device smaller can make implantation easier, but it can also leave less room for sensors and wireless components. Making the device larger can improve performance but may require a more invasive procedure.
MiFi's foldable design attempts to overcome this compromise by allowing the implant to be compact during insertion and larger when it is performing its job.
In the future, similar technology could potentially be used to monitor multiple signals from inside the body at the same time. Such systems could provide doctors with more continuous information about a patient's condition and reduce the need for some repeated procedures.
The technology could be particularly valuable for personalized healthcare, where treatment decisions are increasingly based on information collected from individual patients.
The researchers say their approach could eventually enable multiple types of biological measurements through quick, suture-free insertion procedures.
Looking Ahead
MiFi represents an intriguing step toward a new generation of miniature medical implants. Its origami-inspired structure allows it to solve a difficult engineering problem: being small enough to insert with minimal disruption while expanding to provide enough space for sensors and wireless electronics.
Its ability to operate without a bulky battery and monitor several biological signals adds further potential.
However, significant development remains before such a system could be used routinely in people. Researchers will need to establish how safely the device can be implanted, how long it can function, how accurately it can measure biological signals and whether it can reliably communicate through human tissue.
If these challenges can be overcome, foldable implants such as MiFi could change the way certain health conditions are monitored. Instead of relying only on occasional blood tests or larger implanted devices, doctors could one day use tiny wireless sensors to gather valuable information directly from inside the body.
For now, MiFi remains an experimental technology, but its clever combination of flexible materials, foldable design, wireless power and multiple sensors offers a promising glimpse of what the future of minimally invasive healthcare could look like.
Reference: , , , et al. “ A Geometrically Transient Platform for Bioelectronic Implants.” Advanced Materials (2026): e73923. https://doi.org/10.1002/adma.73923

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